Atypical plasma cholinesterase.

Atypical cholinesterase

Atypical plasma cholinesterase. A personal discovery story: a tale of three cities.

Plasma cholinesterase and malignant hyperthermia.

Sir,—Humphrey, Downing and Brock-Utne (1980) are less than accurate in describing the destiny of expiration switched to inspiration in the Johannesburg Circuit. They vaguely refer to experimental evidence gathered "while studying a similar system"—evidence which simply does not tally with known pharmacokinetic principles. With a fresh gas inflow of 70mlkg~' min"' in a patient weighing 65 kg, th...

A new high activity plasma cholinesterase variant.

A South African Afrikaans speaking family is reported in which a new high activity plasma cholinesterase variant was found to occur in the mother and son. The variant has the same electrophoretic mobility as the "usual' enzyme, but greater heat stability. Its higher specific activity is associated with a normal number of enzyme molecules. The variant may be inherited as a dominant trait, though...

Comparison of Atypical and Usual Human Serum Cholinesterase

Atypical and usual human serum cholinesterases were purified and studied with the fluorescent probe, N-methyl(7-dimethylcarbamoxy)quinolinium iodide. Four active sites per tetramer were found in each enzyme. The turnover numbers of usual and atypical cholinesterases were the same: 15,000 pmol of benzoylcholine hydrol~zedlminl~mol of active site; 48,000 min-’ for o-nitrophenylbutyrate; and 0.002...